What is doravirine (Pifeltro), and how does it work?

Doravirine, sold as Pifeltro, is an NNRTI (non-nucleoside reverse transcriptase inhibitor) that blocks an enzyme HIV needs to replicate, reducing viral load.

What is the role of islatravir in HIV treatment?

Islatravir is a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) that interferes with HIV’s ability to replicate its genetic material, preventing viral multiplication.

How does this combination compare to other HIV therapies like Biktarvy?

The islatravir-doravirine combination was non-inferior to Biktarvy in phase 3 trials, meaning it worked just as well in maintaining viral suppression but wasn’t superior.

Are there any safety concerns with this treatment?

The combination was generally well-tolerated in trials, with mild side effects like nausea and headaches. Patients with hepatitis B should be closely monitored.

When will this combination be available to patients?

Merck is submitting trial data to regulatory agencies like the FDA. If approved, it could become available in the next few years.

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A Simpler Path to HIV Treatment: Merck’s Promising Two-Drug Combo Shows Strong Phase 3 Results

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Advances in HIV Treatment

Discover Merck's innovative two-drug HIV treatment, combining islatravir and doravirine. Promising phase 3 results show simpler, effective daily management.

Published:January 14th, 2025

Read time:8 min